Synergistic <i>in vitro</i> anticancer actions of decorated selenium nanoparticles with fucoidan/Reishi extract against colorectal adenocarcinoma cells

Abstract Cancer-fighting needs more effective and targeted drugs, desirably with least side-effects from natural bases. The assessment synergistic actions of multiple anticancer drug candidates were investigated. Fucoidan (Fu) was extracted Sargassum cinereum , which attained the Saudi Red-Sea coast. extract Ganoderma lucidum or Reishi mushroom (Re) achieved, intermixed Fu solution, they used for reducing/decorating/capping selenium nanoparticles (SeNPs). infrared analysis produced/synthesized agents emphasized their biochemical structures interactions. decorated Fu/Re/SeNPs had negative (−30.6 mV) zeta potential SeNPs mean particle size 6.5 nm. transmission imaging indicated spherical profiles well-dispersion within Fu/Re composite. potentiality against human colorectal adenocarcinoma cells investigated using MTT, 4′,6-diamidino-2-phenylindole staining comet assay. Both composites exhibited potent bioactivities toward cells; reduced survival detected IC 50 57.82 16.43 µg·mL −1 Fu/Re/SeNPs, respectively. constrained apoptosis notably observed treated composites; substantial molecular damages also verified via assay, especially in cells. innovative innocuous composite is highly recommended to deactivate/destruct